It's easy to create a one off design, or design an entire album with DesignMatic.
1 - Fill openings will automatically start filling the openings with "Fill Advanced" If you would like to alter the design before filling, uncheck this box.
2- Choose the design.
3 - Click Single Page
As you can see the design has been made and a modified "Fill Advanced" has been launched.
For this demonstration, I'll use "No Action", but you can use any of the functions in "Fill Advanced" that you see here. For more info on fill advanced, see here.
As you can see, the design will automatically cycle through all boxes until the design is full, then it will stop.